Scientists: "Maybe this shit really did leak out of that fuckin lab."
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Poast new message in this thread
Date: March 25th, 2020 11:56 PM Author: fighting shaky church
This is an example of how lazy and biased most journalists are. They don't want to blame this on China so they rather than investigate, they ask some "expert" with the same bias, quote them, and then conclude everyone who says differently is "fake news."
Is it entirely possible that the virus originated from a bat that was at the wet market without any relation to the Wuhan lab? Yes.
But statistically, of all the markets in Asia, what are the odds this incident "occurred" in the market that is literally 3 football fields away from a lab where the Chinese were experimenting with Corona viruses in bats?
We're looking at probably at least a 1/1000 coincidence?
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865000) |
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Date: March 26th, 2020 12:06 AM Author: fighting shaky church
^^^Not a res ipso loquitor scholar
At a certain point when a coincidence becomes incredible you have to be smart and realize it might not be a coincidence?
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865047)
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Date: March 26th, 2020 12:14 AM Author: fighting shaky church
To summarize:
You argument = It was a million to one shot, and this time we "won" the lottery
My argument = The bat virus somehow got out of the lab that was across the street from where the outbreak occurred.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865114) |
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Date: March 26th, 2020 12:17 AM Author: Indigo Locus Macaca
285 meters isn't across the street, but either way, there are virus labs at every major research university in the world.
why do you think they were studying these viruses at this lab? because they were present in wild animal populations in that region and posed a threat of spread, so they wanted to understand the threat better.
i'm not saying it wasn't from the lab, but that seafood market sold bats and pangolins. would be a coincidence if it didn't come from there, too.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865132) |
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Date: March 26th, 2020 12:26 AM Author: Indigo Locus Macaca
...and they have been spreading plagues that way for millennia. avian flu and SARS underwent zoonosis in China as well. The "Spanish" flu may have originated in China:
https://en.wikipedia.org/wiki/Spanish_flu#China
And many postulate that the Black Death spread the same way:
https://www.nytimes.com/2010/11/01/health/01plague.html
Europe’s Plagues Came From China, Study Finds
The great waves of plague that twice devastated Europe and changed the course of history had their origins in China, a team of medical geneticists reported Sunday, as did a third plague outbreak that struck less harmfully in the 19th century.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865179) |
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Date: March 26th, 2020 12:33 AM Author: Indigo Locus Macaca
no
The viral outbreak can be genetically traced to a colony of cave-dwelling horseshoe bats in China's Yunnan province.[26]
The SARS epidemic appears to have started in Guangdong Province, China, in November 2002 where the first case was reported that same month. The patient, a farmer from Shunde, Foshan, Guangdong, was treated in the First People's Hospital of Foshan. The patient died soon after, and no definite diagnosis was made on his cause of death.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865211) |
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Date: March 26th, 2020 12:22 AM Author: unholy business firm
"there are virus labs at every major research university in the world". Not like the virus lab in Wuhan. It is the only lab of its kind in the entire world.
Inside the Chinese lab poised to study world's most dangerous pathogens
Maximum-security biolab is part of plan to build network of BSL-4 facilities across China
A laboratory in Wuhan is on the cusp of being cleared to work with the world’s most dangerous pathogens. The move is part of a plan to build between five and seven biosafety level-4 (BSL-4) labs across the Chinese mainland by 2025, and has generated much excitement, as well as some concerns.
Related stories
Ebola spurs creation of Japan's first maximum-security biolab
European biosafety labs set to grow
Booming biosafety labs probed
More related stories
Some scientists outside China worry about pathogens escaping, and the addition of a biological dimension to geopolitical tensions between China and other nations. But Chinese microbiologists are celebrating their entrance to the elite cadre empowered to wrestle with the world’s greatest biological threats.
“It will offer more opportunities for Chinese researchers, and our contribution on the BSL‑4-level pathogens will benefit the world,” says George Gao, director of the Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology in Beijing. There are already two BSL-4 labs in Taiwan, but the National Bio-safety Laboratory, Wuhan, would be the first on the Chinese mainland.
The lab was certified as meeting the standards and criteria of BSL-4 by the China National Accreditation Service for Conformity Assessment (CNAS) in January. The CNAS examined the lab’s infrastructure, equipment and management, says a CNAS representative, paving the way for the Ministry of Health to give its approval. A representative from the ministry says it will move slowly and cautiously; if the assessment goes smoothly, it could approve the laboratory by the end of June.
BSL-4 is the highest level of biocontainment: its criteria include filtering air and treating water and waste before they leave the laboratory, and stipulating that researchers change clothes and shower before and after using lab facilities. Such labs are often controversial. The first BSL-4 lab in Japan was built in 1981, but operated with lower-risk pathogens until 2015, when safety concerns were finally overcome.
The expansion of BSL-4-lab networks in the United States and Europe over the past 15 years — with more than a dozen now in operation or under construction in each region — also met with resistance, including questions about the need for so many facilities.
“Viruses don’t know borders.”
The Wuhan lab cost 300 million yuan (US$44 million), and to allay safety concerns it was built far above the flood plain and with the capacity to withstand a magnitude-7 earthquake, although the area has no history of strong earthquakes. It will focus on the control of emerging diseases, store purified viruses and act as a World Health Organization ‘reference laboratory’ linked to similar labs around the world. “It will be a key node in the global biosafety-lab network,” says lab director Yuan Zhiming.
The Chinese Academy of Sciences approved the construction of a BSL-4 laboratory in 2003, and the epidemic of SARS (severe acute respiratory syndrome) around the same time lent the project momentum. The lab was designed and constructed with French assistance as part of a 2004 cooperative agreement on the prevention and control of emerging infectious diseases. But the complexity of the project, China’s lack of experience, difficulty in maintaining funding and long government approval procedures meant that construction wasn’t finished until the end of 2014.
The lab’s first project will be to study the BSL-3 pathogen that causes Crimean–Congo haemorrhagic fever: a deadly tick-borne virus that affects livestock across the world, including in northwest China, and that can jump to people.
Future plans include studying the pathogen that causes SARS, which also doesn’t require a BSL-4 lab, before moving on to Ebola and the West African Lassa virus, which do. Some one million Chinese people work in Africa; the country needs to be ready for any eventuality, says Yuan. “Viruses don’t know borders.”
Gao travelled to Sierra Leone during the recent Ebola outbreak, allowing his team to report the speed with which the virus mutated into new strains1. The Wuhan lab will give his group a chance to study how such viruses cause disease, and to develop treatments based on antibodies and small molecules, he says.
Muyi Xiao for Nature
The central monitor room at China’s National Bio-safety Laboratory.
The opportunities for international collaboration, meanwhile, will aid the genetic analysis and epidemiology of emergent diseases. “The world is facing more new emerging viruses, and we need more contribution from China,” says Gao. In particular, the emergence of zoonotic viruses — those that jump to humans from animals, such as SARS or Ebola — is a concern, says Bruno Lina, director of the VirPath virology lab in Lyon, France.
Many staff from the Wuhan lab have been training at a BSL-4 lab in Lyon, which some scientists find reassuring. And the facility has already carried out a test-run using a low-risk virus.
But worries surround the Chinese lab, too. The SARS virus has escaped from high-level containment facilities in Beijing multiple times, notes Richard Ebright, a molecular biologist at Rutgers University in Piscataway, New Jersey. Tim Trevan, founder of CHROME Biosafety and Biosecurity Consulting in Damascus, Maryland, says that an open culture is important to keeping BSL-4 labs safe, and he questions how easy this will be in China, where society emphasizes hierarchy. “Diversity of viewpoint, flat structures where everyone feels free to speak up and openness of information are important,” he says.
Yuan says that he has worked to address this issue with staff. “We tell them the most important thing is that they report what they have or haven’t done,” he says. And the lab’s international collaborations will increase openness. “Transparency is the basis of the lab,” he adds.
The plan to expand into a network heightens such concerns. One BSL-4 lab in Harbin is already awaiting accreditation; the next two are expected to be in Beijing and Kunming, the latter focused on using monkey models to study disease.
Lina says that China’s size justifies this scale, and that the opportunity to combine BSL-4 research with an abundance of research monkeys — Chinese researchers face less red tape than those in the West when it comes to research on primates — could be powerful. “If you want to test vaccines or antivirals, you need a non-human primate model,” says Lina.
But Ebright is not convinced of the need for more than one BSL-4 lab in mainland China. He suspects that the expansion there is a reaction to the networks in the United States and Europe, which he says are also unwarranted. He adds that governments will assume that such excess capacity is for the potential development of bioweapons.
“These facilities are inherently dual use,” he says. The prospect of ramping up opportunities to inject monkeys with pathogens also worries, rather than excites, him: “They can run, they can scratch, they can bite.”
Trevan says China’s investment in a BSL-4 lab may, above all, be a way to prove to the world that the nation is competitive. “It is a big status symbol in biology,” he says, “whether it’s a need or not.”
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865158) |
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Date: April 17th, 2020 12:49 AM Author: unholy business firm
Date: March 26th, 2020 12:17 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
285 meters isn't across the street, but either way, there are virus labs at every major research university in the world.
why do you think they were studying these viruses at this lab? because they were present in wild animal populations in that region and posed a threat of spread, so they wanted to understand the threat better.
i'm not saying it wasn't from the lab, but that seafood market sold bats and pangolins. would be a coincidence if it didn't come from there, too.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865132)
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40032522) |
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Date: March 26th, 2020 12:01 AM Author: Bateful lavender karate
you forgot the most interesting and imo the most important fact about this virus
-- it was able to recognize human ACE2 from DAY ONE unlike SARS which had to mutate and figure out that ACE2 was the way to go
"When SARS-classic first made this leap, a brief period of mutation was necessary for it to recognize ACE2 well. But SARS-CoV-2 could do that from day one. “It had already found its best way of being a [human] virus,” says Matthew Frieman of the University of Maryland School of Medicine."
https://www.theatlantic.com/science/archive/2020/03/biography-new-coronavirus/608338/
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865021) |
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Date: March 26th, 2020 12:09 AM Author: Bateful lavender karate
i dont know what to think but top notch scientist (andersen of scripss) thinks that we were very unlucky and got got by a "very low" probability event. so it comes down how much do you believe in very low probability events
"What are the odds that a random bat virus had exactly the right combination of traits to effectively infect human cells from the get-go, and then jump into an unsuspecting person? “Very low,” Andersen says,
https://andersen-lab.com/
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865070) |
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Date: April 17th, 2020 12:47 AM Author: unholy business firm
Date: March 26th, 2020 12:37 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
I was lucky to fall in with some very accomplished people in grad school
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865240)
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40032510) |
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Date: April 17th, 2020 12:48 AM Author: unholy business firm
Date: March 26th, 2020 12:22 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
i have a STEM PhD, and have co-authored papers published in Science and PNAS.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865159)
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40032516) |
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Date: April 17th, 2020 12:51 AM Author: unholy business firm
Date: March 26th, 2020 12:14 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
i'm not saying it came from the lab. but if it did come from the lab, that lab virus came from a wild bat via a wild pangolin, so it was circulating in the wild anyway. would've been a matter of time before it found its way into that seafood market anyway, since it has bats and pangolins in stock.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40032531) |
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Date: April 17th, 2020 7:58 PM Author: unholy business firm
Date: March 26th, 2020 12:38 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
i'm just shit-talking him. but unless he possesses doctoral-level knowledge of statistics, then i probably do. and he's not making any sense.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40037574) |
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Date: April 17th, 2020 7:58 PM Author: unholy business firm
Date: March 26th, 2020 12:41 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
no, you are just being really incoherent, there is not much to engage. sorry man.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40037581)
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Date: April 17th, 2020 7:57 PM Author: unholy business firm
Date: March 26th, 2020 12:19 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
the wet market part is irrelevant if you think it came from the lab
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40037569) |
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Date: March 26th, 2020 12:20 AM Author: Bateful lavender karate
how many of them did this kind of research like the wuhan lab did? just a freaky coincidence we have a bat coronavirus pandemic originate in wuhan
"Engineered bat virus stirs debate over risky research"
https://www.nature.com/news/engineered-bat-virus-stirs-debate-over-risky-research-1.18787?WT.mc_id=TWT_NatureNews
In an article published in Nature Medicine1 on 9 November, scientists investigated a virus called SHC014, which is found in horseshoe bats in China. The researchers created a chimaeric virus, made up of a surface protein of SHC014 and the backbone of a SARS virus that had been adapted to grow in mice and to mimic human disease. The chimaera infected human airway cells — proving that the surface protein of SHC014 has the necessary structure to bind to a key receptor on the cells and to infect them.
Although the extent of any risk is difficult to assess, Simon Wain-Hobson, a virologist at the Pasteur Institute in Paris, points out that the researchers have created a novel virus that “grows remarkably well” in human cells. “If the virus escaped, nobody could predict the trajectory,” he says.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865145) |
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Date: March 26th, 2020 12:30 AM Author: Bateful lavender karate
you said bats are studied in every lab. how many of them created artificial coronavirus to test if the could infect humans? since you think this kind of research nbd link to such research by other labs or stfu. also FDA banned this kind of research because they realized how dangerous it is. this particular experiment was grandfathered in
so we have a pandemic coronavirus break out from the one city in china which happens to have a BSL4 lab and also the same lab that created an artifical coronavirus that could infect humans easily which raised red flags even then and some how this new coronavirus can also infect humans very easily. coincidece? possible but if you are not somewhat suspicious you have an agenda or you are dumb. at the minimum we shouldnt rush to conclusions a few months after the out break. why is everybody ruling this out so fast when we dont even have a complete picture of this virus?
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865197)
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Date: March 26th, 2020 12:43 AM Author: Bateful lavender karate
it doesnt conclusively show anything. it only shows that pieces of this virus is naturally present in different animals. the protein spike is from pangolin and the rest from the bat
I am not sure how the author then jumps to the conclusion its not possible to produce this in a lab. bioweapon research could have specifically manipulated these two naturally occurring parts into a single artificial virus. its extremely unlikely that this is a bioweapon but i dont understand how you can completely rule it out at this stage
so for nobody has found the animal that has this virus. until then you have assume that one possible scenario is that this could be artifically created even if its highly improbable.
i am not saying that its a bioweapon that escaped but all i am saying is that dont rule it out. yet
"However, since we observed all notable SARS-CoV-2 features, including the optimized RBD and polybasic cleavage site, in related coronaviruses in nature, we do not believe that any type of laboratory-based scenario is plausible."
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865272) |
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Date: April 17th, 2020 7:58 PM Author: unholy business firm
Date: March 26th, 2020 12:23 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
it makes sense that they would be studying the viruses that are endemic to wildlife nearby.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40037586)
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Date: March 26th, 2020 12:27 AM Author: unholy business firm
oh yeah. this research happens all over!
Inside the Chinese lab poised to study world's most dangerous pathogens
Maximum-security biolab is part of plan to build network of BSL-4 facilities across China
A laboratory in Wuhan is on the cusp of being cleared to work with the world’s most dangerous pathogens. The move is part of a plan to build between five and seven biosafety level-4 (BSL-4) labs across the Chinese mainland by 2025, and has generated much excitement, as well as some concerns.
Related stories
Ebola spurs creation of Japan's first maximum-security biolab
European biosafety labs set to grow
Booming biosafety labs probed
More related stories
Some scientists outside China worry about pathogens escaping, and the addition of a biological dimension to geopolitical tensions between China and other nations. But Chinese microbiologists are celebrating their entrance to the elite cadre empowered to wrestle with the world’s greatest biological threats.
“It will offer more opportunities for Chinese researchers, and our contribution on the BSL‑4-level pathogens will benefit the world,” says George Gao, director of the Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology in Beijing. There are already two BSL-4 labs in Taiwan, but the National Bio-safety Laboratory, Wuhan, would be the first on the Chinese mainland.
The lab was certified as meeting the standards and criteria of BSL-4 by the China National Accreditation Service for Conformity Assessment (CNAS) in January. The CNAS examined the lab’s infrastructure, equipment and management, says a CNAS representative, paving the way for the Ministry of Health to give its approval. A representative from the ministry says it will move slowly and cautiously; if the assessment goes smoothly, it could approve the laboratory by the end of June.
BSL-4 is the highest level of biocontainment: its criteria include filtering air and treating water and waste before they leave the laboratory, and stipulating that researchers change clothes and shower before and after using lab facilities. Such labs are often controversial. The first BSL-4 lab in Japan was built in 1981, but operated with lower-risk pathogens until 2015, when safety concerns were finally overcome.
The expansion of BSL-4-lab networks in the United States and Europe over the past 15 years — with more than a dozen now in operation or under construction in each region — also met with resistance, including questions about the need for so many facilities.
“Viruses don’t know borders.”
The Wuhan lab cost 300 million yuan (US$44 million), and to allay safety concerns it was built far above the flood plain and with the capacity to withstand a magnitude-7 earthquake, although the area has no history of strong earthquakes. It will focus on the control of emerging diseases, store purified viruses and act as a World Health Organization ‘reference laboratory’ linked to similar labs around the world. “It will be a key node in the global biosafety-lab network,” says lab director Yuan Zhiming.
The Chinese Academy of Sciences approved the construction of a BSL-4 laboratory in 2003, and the epidemic of SARS (severe acute respiratory syndrome) around the same time lent the project momentum. The lab was designed and constructed with French assistance as part of a 2004 cooperative agreement on the prevention and control of emerging infectious diseases. But the complexity of the project, China’s lack of experience, difficulty in maintaining funding and long government approval procedures meant that construction wasn’t finished until the end of 2014.
The lab’s first project will be to study the BSL-3 pathogen that causes Crimean–Congo haemorrhagic fever: a deadly tick-borne virus that affects livestock across the world, including in northwest China, and that can jump to people.
Future plans include studying the pathogen that causes SARS, which also doesn’t require a BSL-4 lab, before moving on to Ebola and the West African Lassa virus, which do. Some one million Chinese people work in Africa; the country needs to be ready for any eventuality, says Yuan. “Viruses don’t know borders.”
Gao travelled to Sierra Leone during the recent Ebola outbreak, allowing his team to report the speed with which the virus mutated into new strains1. The Wuhan lab will give his group a chance to study how such viruses cause disease, and to develop treatments based on antibodies and small molecules, he says.
Muyi Xiao for Nature
The central monitor room at China’s National Bio-safety Laboratory.
The opportunities for international collaboration, meanwhile, will aid the genetic analysis and epidemiology of emergent diseases. “The world is facing more new emerging viruses, and we need more contribution from China,” says Gao. In particular, the emergence of zoonotic viruses — those that jump to humans from animals, such as SARS or Ebola — is a concern, says Bruno Lina, director of the VirPath virology lab in Lyon, France.
Many staff from the Wuhan lab have been training at a BSL-4 lab in Lyon, which some scientists find reassuring. And the facility has already carried out a test-run using a low-risk virus.
But worries surround the Chinese lab, too. The SARS virus has escaped from high-level containment facilities in Beijing multiple times, notes Richard Ebright, a molecular biologist at Rutgers University in Piscataway, New Jersey. Tim Trevan, founder of CHROME Biosafety and Biosecurity Consulting in Damascus, Maryland, says that an open culture is important to keeping BSL-4 labs safe, and he questions how easy this will be in China, where society emphasizes hierarchy. “Diversity of viewpoint, flat structures where everyone feels free to speak up and openness of information are important,” he says.
Yuan says that he has worked to address this issue with staff. “We tell them the most important thing is that they report what they have or haven’t done,” he says. And the lab’s international collaborations will increase openness. “Transparency is the basis of the lab,” he adds.
The plan to expand into a network heightens such concerns. One BSL-4 lab in Harbin is already awaiting accreditation; the next two are expected to be in Beijing and Kunming, the latter focused on using monkey models to study disease.
Lina says that China’s size justifies this scale, and that the opportunity to combine BSL-4 research with an abundance of research monkeys — Chinese researchers face less red tape than those in the West when it comes to research on primates — could be powerful. “If you want to test vaccines or antivirals, you need a non-human primate model,” says Lina.
But Ebright is not convinced of the need for more than one BSL-4 lab in mainland China. He suspects that the expansion there is a reaction to the networks in the United States and Europe, which he says are also unwarranted. He adds that governments will assume that such excess capacity is for the potential development of bioweapons.
“These facilities are inherently dual use,” he says. The prospect of ramping up opportunities to inject monkeys with pathogens also worries, rather than excites, him: “They can run, they can scratch, they can bite.”
Trevan says China’s investment in a BSL-4 lab may, above all, be a way to prove to the world that the nation is competitive. “It is a big status symbol in biology,” he says, “whether it’s a need or not.”
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865184) |
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Date: March 26th, 2020 12:40 AM Author: Indigo Locus Macaca
"The most dangerous lab in the world"
You just made that up
" a batcoronavirus-sars hybrid engineered to infect human cells"
that is completely dissimilar from this virus
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865258)
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Date: March 26th, 2020 1:39 AM Author: unholy business firm
"a batcoronavirus-sars hybrid engineered to infect human cells""that is completely dissimilar from this virus"
You are retarded. The point isn't that the virus that is causing the plague was engineered to infect human cells. Its that this lab was clearly known for producing a long line of research about bat coronaviruses, to the point where you could say that was their speciality. and it just so happens that this type of virus allegedly originated at a wet market right next to lab! oh what do you know, its a miracle!
"The most dangerous lab in the world" -"You just made that up"
Oh really?
Inside the Chinese lab poised to study world's most dangerous pathogens
Maximum-security biolab is part of plan to build network of BSL-4 facilities across China
A laboratory in Wuhan is on the cusp of being cleared to work with the world’s most dangerous pathogens. The move is part of a plan to build between five and seven biosafety level-4 (BSL-4) labs across the Chinese mainland by 2025, and has generated much excitement, as well as some concerns.
Some scientists outside China worry about pathogens escaping, and the addition of a biological dimension to geopolitical tensions between China and other nations. But Chinese microbiologists are celebrating their entrance to the elite cadre empowered to wrestle with the world’s greatest biological threats.
“It will offer more opportunities for Chinese researchers, and our contribution on the BSL‑4-level pathogens will benefit the world,” says George Gao, director of the Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology in Beijing. There are already two BSL-4 labs in Taiwan, but the National Bio-safety Laboratory, Wuhan, would be the first on the Chinese mainland.
The lab was certified as meeting the standards and criteria of BSL-4 by the China National Accreditation Service for Conformity Assessment (CNAS) in January. The CNAS examined the lab’s infrastructure, equipment and management, says a CNAS representative, paving the way for the Ministry of Health to give its approval. A representative from the ministry says it will move slowly and cautiously; if the assessment goes smoothly, it could approve the laboratory by the end of June.
BSL-4 is the highest level of biocontainment: its criteria include filtering air and treating water and waste before they leave the laboratory, and stipulating that researchers change clothes and shower before and after using lab facilities. Such labs are often controversial. The first BSL-4 lab in Japan was built in 1981, but operated with lower-risk pathogens until 2015, when safety concerns were finally overcome.
The expansion of BSL-4-lab networks in the United States and Europe over the past 15 years — with more than a dozen now in operation or under construction in each region — also met with resistance, including questions about the need for so many facilities.
“Viruses don’t know borders.”
The Wuhan lab cost 300 million yuan (US$44 million), and to allay safety concerns it was built far above the flood plain and with the capacity to withstand a magnitude-7 earthquake, although the area has no history of strong earthquakes. It will focus on the control of emerging diseases, store purified viruses and act as a World Health Organization ‘reference laboratory’ linked to similar labs around the world. “It will be a key node in the global biosafety-lab network,” says lab director Yuan Zhiming.
The Chinese Academy of Sciences approved the construction of a BSL-4 laboratory in 2003, and the epidemic of SARS (severe acute respiratory syndrome) around the same time lent the project momentum. The lab was designed and constructed with French assistance as part of a 2004 cooperative agreement on the prevention and control of emerging infectious diseases. But the complexity of the project, China’s lack of experience, difficulty in maintaining funding and long government approval procedures meant that construction wasn’t finished until the end of 2014.
The lab’s first project will be to study the BSL-3 pathogen that causes Crimean–Congo haemorrhagic fever: a deadly tick-borne virus that affects livestock across the world, including in northwest China, and that can jump to people.
Future plans include studying the pathogen that causes SARS, which also doesn’t require a BSL-4 lab, before moving on to Ebola and the West African Lassa virus, which do. Some one million Chinese people work in Africa; the country needs to be ready for any eventuality, says Yuan. “Viruses don’t know borders.”
Gao travelled to Sierra Leone during the recent Ebola outbreak, allowing his team to report the speed with which the virus mutated into new strains1. The Wuhan lab will give his group a chance to study how such viruses cause disease, and to develop treatments based on antibodies and small molecules, he says.
Muyi Xiao for Nature
The central monitor room at China’s National Bio-safety Laboratory.
The opportunities for international collaboration, meanwhile, will aid the genetic analysis and epidemiology of emergent diseases. “The world is facing more new emerging viruses, and we need more contribution from China,” says Gao. In particular, the emergence of zoonotic viruses — those that jump to humans from animals, such as SARS or Ebola — is a concern, says Bruno Lina, director of the VirPath virology lab in Lyon, France.
Many staff from the Wuhan lab have been training at a BSL-4 lab in Lyon, which some scientists find reassuring. And the facility has already carried out a test-run using a low-risk virus.
But worries surround the Chinese lab, too. The SARS virus has escaped from high-level containment facilities in Beijing multiple times, notes Richard Ebright, a molecular biologist at Rutgers University in Piscataway, New Jersey. Tim Trevan, founder of CHROME Biosafety and Biosecurity Consulting in Damascus, Maryland, says that an open culture is important to keeping BSL-4 labs safe, and he questions how easy this will be in China, where society emphasizes hierarchy. “Diversity of viewpoint, flat structures where everyone feels free to speak up and openness of information are important,” he says.
Yuan says that he has worked to address this issue with staff. “We tell them the most important thing is that they report what they have or haven’t done,” he says. And the lab’s international collaborations will increase openness. “Transparency is the basis of the lab,” he adds.
The plan to expand into a network heightens such concerns. One BSL-4 lab in Harbin is already awaiting accreditation; the next two are expected to be in Beijing and Kunming, the latter focused on using monkey models to study disease.
Lina says that China’s size justifies this scale, and that the opportunity to combine BSL-4 research with an abundance of research monkeys — Chinese researchers face less red tape than those in the West when it comes to research on primates — could be powerful. “If you want to test vaccines or antivirals, you need a non-human primate model,” says Lina.
But Ebright is not convinced of the need for more than one BSL-4 lab in mainland China. He suspects that the expansion there is a reaction to the networks in the United States and Europe, which he says are also unwarranted. He adds that governments will assume that such excess capacity is for the potential development of bioweapons.
“These facilities are inherently dual use,” he says. The prospect of ramping up opportunities to inject monkeys with pathogens also worries, rather than excites, him: “They can run, they can scratch, they can bite.”
Trevan says China’s investment in a BSL-4 lab may, above all, be a way to prove to the world that the nation is competitive. “It is a big status symbol in biology,” he says, “whether it’s a need or not.”
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865564)
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Date: March 26th, 2020 1:35 AM Author: unholy business firm
SARS-CoV is a select agent. All work for these studies was performed with approved standard operating procedures (SOPs) and safety conditions for SARS-CoV, MERs-CoV and other related CoVs. Our institutional CoV BSL3 facilities have been designed to conform to the safety requirements that are recommended in the Biosafety in Microbiological and Biomedical Laboratories (BMBL), the US Department of Health and Human Services, the Public Health Service, the Centers for Disease Control (CDC) and the NIH. Laboratory safety plans were submitted to, and the facility has been approved for use by, the UNC Department of Environmental Health and Safety (EHS) and the CDC. Electronic card access is required for entry into the facility. All workers have been trained by EHS to safely use powered air purifying respirators (PAPRs), and appropriate work habits in a BSL3 facility and active medical surveillance plans are in place. Our CoV BSL3 facilities contain redundant fans, emergency power to fans and biological safety cabinets and freezers, and our facilities can accommodate SealSafe mouse racks. Materials classified as BSL3 agents consist of SARS-CoV, bat CoV precursor strains, MERS-CoV and mutants derived from these pathogens. Within the BSL3 facilities, experimentation with infectious virus is performed in a certified Class II Biosafety Cabinet (BSC). All members of the staff wear scrubs, Tyvek suits and aprons, PAPRs and shoe covers, and their hands are double-gloved. BSL3 users are subject to a medical surveillance plan monitored by the University Employee Occupational Health Clinic (UEOHC), which includes a yearly physical, annual influenza vaccination and mandatory reporting of any symptoms associated with CoV infection during periods when working in the BSL3. All BSL3 users are trained in exposure management and reporting protocols, are prepared to self-quarantine and have been trained for safe delivery to a local infectious disease management department in an emergency situation. All potential exposure events are reported and investigated by EHS and UEOHC, with reports filed to both the CDC and the NIH.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865540) |
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Date: March 26th, 2020 12:53 AM Author: Indigo Locus Macaca
BEEP BEEP BEEP
i'm not attacking your credibility bc of your name.
i'm attacking your credibility because you are an anonymous internet poaster baselessly speculating on a racist lawyer chatbort.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865328) |
Date: March 26th, 2020 12:37 AM Author: Ebony mediation theater
It’s not just the location, there are other things too:
1. The genetic sequence is SARS with HIV spliced into it.
2. The symptoms have been described by a big shot pathologist as eerily like a mixture of SARS and AIDS
3. The most promising treatment is a cocktail of a drug used against SARS (chloroquine) and a drug used against HIV (remdesivir).
4. The very first public step taken by Xi Jinping against this plague was to boost the law about security in bio labs.
5. The location of the lab, the only one of its kind in China.
6. The lab has had multiple pathogen leaks, including 4 documented leaks of SARS and likely a whole bunch of others that were hushed up.
Occams Razor suggests an engineered virus accidentally released.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865244) |
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Date: March 26th, 2020 12:46 AM Author: Indigo Locus Macaca
1 is completely false
3 is lulzy, because remdesivir is an antiviral effective against a range of viruses, not just HIV. also known to be effective against MERS, which is related to SARS-CoV-2: https://www.nih.gov/news-events/news-releases/remdesivir-prevents-mers-coronavirus-disease-monkeys
and not shocking that a drug effective against SARS would be effective against SARS-CoV-2
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865282)
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Date: March 26th, 2020 12:43 AM Author: fighting shaky church
The deniers in this thread keep shrieking "the science is settled it wasn't genetically engineered".
It doesn't have to be genetically engineered. Who is to say the lab wasn't sticking a bunch of bats with a bunch of other animals to see what they could create, and then some janitor throws out a corona virus bat into the dumpster, an someone bring it home and eats it?
That seems much more plausible than a coincidence where this allegedly happened at the one wet market out of thousands that is right next to a coronavirus bat lab.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865274) |
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Date: April 17th, 2020 12:47 AM Author: unholy business firm
Date: March 26th, 2020 12:47 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
it could've leaked, but there is no convincing proof that it did
but it wasn't engineered, which multiple people keep saying here
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865289)
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40032514) |
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Date: April 17th, 2020 8:01 PM Author: unholy business firm
Date: March 26th, 2020 12:47 AM
Author: ,.,...,..,.,.,:,.,,.,.,:;,......;,..,;,:..:,::,.
it could've leaked, but there is no convincing proof that it did
but it wasn't engineered, which multiple people keep saying here
(http://www.autoadmit.com/thread.php?thread_id=#)
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#40037599) |
Date: March 26th, 2020 1:35 AM Author: unholy business firm
SARS-CoV is a select agent. All work for these studies was performed with approved standard operating procedures (SOPs) and safety conditions for SARS-CoV, MERs-CoV and other related CoVs. Our institutional CoV BSL3 facilities have been designed to conform to the safety requirements that are recommended in the Biosafety in Microbiological and Biomedical Laboratories (BMBL), the US Department of Health and Human Services, the Public Health Service, the Centers for Disease Control (CDC) and the NIH. Laboratory safety plans were submitted to, and the facility has been approved for use by, the UNC Department of Environmental Health and Safety (EHS) and the CDC. Electronic card access is required for entry into the facility. All workers have been trained by EHS to safely use powered air purifying respirators (PAPRs), and appropriate work habits in a BSL3 facility and active medical surveillance plans are in place. Our CoV BSL3 facilities contain redundant fans, emergency power to fans and biological safety cabinets and freezers, and our facilities can accommodate SealSafe mouse racks. Materials classified as BSL3 agents consist of SARS-CoV, bat CoV precursor strains, MERS-CoV and mutants derived from these pathogens. Within the BSL3 facilities, experimentation with infectious virus is performed in a certified Class II Biosafety Cabinet (BSC). All members of the staff wear scrubs, Tyvek suits and aprons, PAPRs and shoe covers, and their hands are double-gloved. BSL3 users are subject to a medical surveillance plan monitored by the University Employee Occupational Health Clinic (UEOHC), which includes a yearly physical, annual influenza vaccination and mandatory reporting of any symptoms associated with CoV infection during periods when working in the BSL3. All BSL3 users are trained in exposure management and reporting protocols, are prepared to self-quarantine and have been trained for safe delivery to a local infectious disease management department in an emergency situation. All potential exposure events are reported and investigated by EHS and UEOHC, with reports filed to both the CDC and the NIH.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39865545) |
Date: March 26th, 2020 9:21 AM Author: Rose Irradiated Keepsake Machete Sandwich
I think the most compelling argument I've seen is the one someone posted from James Woods. The video he tweeted talked not only about the fact that the odds of the virus happening to start in a wet market that close to a virology lab in a country just about the size of ours is as suspicious as you can get. But also that the virus itself is largely only harmful to the very old and already sick (ie the drains on a heavily overpopulated country). Very odd for a virus like this to not affect the very young.
My guess is they were working on a virus that might conveniently take care of their population issues, but it wasn't ready yet or was still just in a "thinking about it" stage and was accidentally released.
(http://www.autoadmit.com/thread.php?thread_id=4487723&forum_id=2#39866616) |
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